While previous research hinted on the link between aspirin and improved cancer survival, a studio Published in nature last week explains why. However, experts careful that aspirin is not a cure – and carries risks such as increased potential for internal bleeding.
So, how can aspirin keep cancer to spread? And what does that mean for future treatments?
What did the studies find the use of aspirin and cancer?
Recent studies found as aspirin, widely used painful, can help prevent the spread of cancer, Although it is unclear whether it would work the same for all types of diseases.
Researchers are investigating this relationship for decades. The First clinical studyPublished in 1988. year, it showed that the regular use of aspirin significantly reduced the risk of colorectal cancer, although the main reason remained unclear.
Now, a new study from the University of Cambridge offers more insight. He found a mechanism that aspirin can help prevent spreading cancer, the process known as metastasis.
Metastasis is responsible for the majority Cancer-related deathsAs cancer cells separate from the original tumor and try to attend elsewhere across the body.
How can these cancer attacks are attacked, aspirin can improve the natural body’s ability to fight back, holding cell cells to abolish more bodies.
How can aspirin keep cancer to expand?
The key of Aspirin’s effect on cancer lies in the body’s immune system, a complex network of cells and proteins defending against infections, diseases and harmful wires.
When cancer cells separate from the tumor, they enter the bloodstream, where the immune system – especially the types of white blood cells known as T-cells – usually hunting them and destroy them. However, platelets – tiny fragments of the blood cell to help in clotting – can interfere with this process.
Cancer exploits thrombocides by initiating an answer similar to injury. When the platelets discover the free cells of cancer, rushes to kay, similarly to cover the wound to stop bleeding.
This creates a protective shield, which makes it difficult for the immune system to recognize and attack cancer cells. In addition, platelets release signals that suppress T-cells, preventing them from doing their job.
Aspirin disrupts the cancer attempts to be cunningly reduced the production of molecules that platelets use to combat immune activity. With platelets weakened, T-cells return their ability to recognize and destroy cancer cells before they have a chance to form new tumors.
How can aspirin be used against cancer?
The study suggests that aspirin can be used after treatment such as surgery where tumors are removed.
This is because some cancer cells have already escaped from tumors and began to settle in other parts of the body, the process known as seeds, where tiny cells are installed in new areas and can later grow into tumors.
However, experts are cautious against directly using aspirin as cancer treatment without further research. With the image of the image any for serious side effects such as internal bleeding because platelet weakening, it can weaken their ability to help blood coal.
Aspirin blocks the molecule that sends platelets to klapa together. Therefore, blood is thinner and increases the risk of uncontrolled bleeding. This is especially dangerous in the stomach, where aspirin can irritate the lining and cause ulcers, and in the brain, where the risk of hemorrhagic stroke is raised if small blood vessels are blowing.
In addition, the study was conducted on mice, not people, so its effects on the spread of cancer should still confirm before it can be recommended for treatment.
“Our research provides a molecular explanation for clinical studies, but Rahul Roychoudhuri said, a professor in Cambridge’s pathology that was part of the nature study.
Several clinical trials, such as Add-Aspirin trial in the UK, Ireland and India, are in progress what patients Most likely will benefit the most than taking aspirin and is working for certain types of cancer.
Roychoudhuri added that he does not anticipate “immediate fast translation” aspirin to cancer treatment.
Is aspirin used against disease in the past?
Some patients with high genetic risks for cancer, such as those with Lynch syndrome (a condition that increases the likelihood of certain cancers) already recommended aspirin as a preventive measure in countries such as Australia and the United Kingdom.
Since the 1980s, aspirin was also prescribed to help Prevent cardiac attacks And they hit in people of high risk of heart disease, reducing platelet ability to form harmful clots that can block blood flow into the heart or brain. This effect of climbing prevention helps reduce the risk Heart strikes in those with the history of cardiovascular diseases.
Does that mean that we are close to the breakthrough in the outburst of cancer?
Not necessarily. While aspirin can help slow down or prevent the spread of cancer, does not remove tumors completely.
However, scientists are working on biomarker identification – measurable signs in blood-and platelet activities to reveal individuals at risk of cancer.
“This would allow timely treatment aspirin, and in minimizing unnecessary exposure for those who do not require that,” Paola Patrignani, Professor of Pharmacology at Gabriele D’Annunzio University in Italy.
Experts say that findings could also contribute to developing drugs that inhibit the spread of cancer.
“Our discovery of open opportunities for the development of targeted therapies that could potentially provide benefits without aspirin side effects,” said Roychoudhuri.
Patrignani, which is involved in research funded by the UK cancer to investigate whether to offer other drug groups, such as clopidogrel, says similar advantages to be needed for another three to five years.
However, it is optimistic in terms of place where the research is moving. “We are on the verge of a significant breakthrough in cancer research. This newfound knowledge could open the way to innovative treatments and potentially save countless lives.”
Why does a cure for cancer stay so elusive?
Finding a drug for cancer remains one of the greatest challenges in medicine.
As there are many different types of cancer, each with its own characteristics and ways of spread, it is difficult to develop a universal medicine.
In addition, the combination of genetic predisposition and environmental factor is affected by the development of tumors. Studies propose That treatment must be personalized to be really effective.
Many rockets are also developing ways to hide From or suppressing the immune system, making them harder with an attack even with immunotherapy.
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2025-03-15 08:56:00
